菌群健康从娃娃抓起?看看这家手握Cell的公司如何做?
编者按
美国微生物组公司 Evolve BioSystems 成立于 2012 年,其希望通过在生命早期阶段干预肠道微生物组,来支持肠道健康。比尔盖茨基金会、李嘉诚基金会、嘉吉等机构或公司都投资了该公司。为何该公司如此被看好?背后的科学秘密是什么?
专注于孩子的肠道微生物组
从双歧杆菌开始的科学
从肠道炎症到自身免疫疾病
从婴儿到动物
(滑动查看更多)
1.https://www.evolvebiosystems.com/news/2021/2/8/evolve-biosystems-announces-major-strategic-investment-from-cargill-and-manna-tree-to-support-innovative-probiotic-that-dramatically-improves-infant-gut-health
2.https://www.signalhire.com/profiles/david-kyle%27s-email/14974712
3.“Births – Method of Delivery.” National Center for Health Statistics. Centers for Disease Control and Prevention. 7 October 2016. Available at: https://www.cdc.gov/nchs/fastats/delivery.htm. Last accessed 10 March 2017.
4.Breastfeeding Report Card – United States 2014. Centers for Disease Control and Prevention. Available at: https://www.cdc.gov/breastfeeding/pdf/2014breastfeedingreportcard.pdf
5.“CDC: 1 in 3 antibiotic prescriptions unnecessary.” CDC Newsroom. Centers for Disease Control and Prevention. 3 May 2016. Available at: https://www.cdc.gov/media/releases/2016/p0503-unnecessary-prescriptions.html. Last accessed 10 March 2017.
6.https://www.evivo.com/professional/b-infantis-benefits
7.Smilowitz JT, Lebrilla CB, Mills DA et al. Breast milk oligosaccharides: structure-function relationships in the neonate. Annu Rev Nutr. 2014;34:143-169.
8.Pammi M, Cope J, Tarr PI et al. Intestinal dysbiosis in preterm infants preceding necrotizing enterocolitis: a systematic review and meta-analysis. Microbiome. 2017;5(1):31.
9.Frese S A, Hutton A A, Contreras L N, et al. Persistence of Supplemented Bifidobacterium longum subsp. infantis EVC001 in Breastfed Infants[J]. mSphere, 2017, 2(6).
10.Smilowitz JT, Moya J, Breck MA et al. Safety and tolerability of Bifidobacterium longum subspecies infantis EVC001 supplementation in healthy term breastfed infants: a phase I clinical trial. BMC Pediatr. 2017;17(1):133. doi: 10.1186/s12887-017-0886-9.
11.Henrick B M, Chew S, Casaburi G, et al. Colonization by B. infantis EVC001 modulates enteric inflammation in exclusively breastfed infants[J]. Pediatric Research, 2019, 86(6):749-757.
12.https://clinicaltrials.gov/ct2/show/NCT04769037
13.https://clinicaltrials.gov/ct2/show/NCT04662619
14.https://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=8197872.PN.&OS=PN/8197872&RS=PN/8197872
15.https://www.evivo.com/